These two inbred strains were selected based on their geographic origin, karyotype, and use in. Click the track search button to find genome browser tracks that match specific selection criteria. Mus musculus article about mus musculus by the free. Mus musculus castaneus an overview sciencedirect topics. The house mouse mus musculus is a common rodent that is distributed throughout the world. Long terminal repeat retrotransposons of mus musculus.
G proteincoupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids scfas, and that plays a role in the regulation of wholebody energy homeostasis and in intestinal immunity. This use has increased in recent years with the development of techniques to successfully modify the mouse genome. In brief, reads were mapped against the mouse mm10 genome reference sequence. It is particularly good at aligning reads of about 50 up to 100s or 1,000s of characters, and particularly good at aligning to relatively long e. Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cellfate specification, progenitorcell proliferation and the control of asymmetric cell division, in many different species and organs. Mus musculus mouse genome info pathway map brite hierarchy module genome map blast taxonomy. This is a rather conservative filter on snp quality, but users are free. Whole genome sequence of two wildderived mus musculus. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common. Pmid 31263278, free pmc article inhibition of trem1 reduces inflammation and oxidative stress after spinal cord injury sci associated with ho1 expressions.
Candidate insulin dependent diabetes regions on chromosomes 1, 3, 4, 6, 11 and 17 have been annotated in both the cl57bl6j reference strain and one or more of nodmrktac, nodshiltj and 129 strains. Mus musculus house mouse the mouse is one of the most useful models for comparison to humans as it is also a mammal. When comparing the mouse genomic sequence with that of hu man, the overall. A genome position can be specified by the accession number of a sequenced genomic region, an mrna or est, a chromosomal coordinate range, or keywords from the genbank description of an mrna. The house mouse mus musculus is a small mammal of the order rodentia, characteristically having. The house mouse mus musculus is a small mammal of the order rodentia, characteristically having a pointed snout, large rounded ears, and a long and hairy tail. The complete mouse reference genome was sequenced in 2002.
They comprise about 8% of the human genome and approximately 10% of the mouse genome. Genomic resources for wild populations of the house mouse, mus. Browse the list download sequence and annotation from refseq or genbank. It is one of the most abundant species of the genus mus. You can easily download the latest protein sequences for mus musculus proteome here. This small rodent probably has a world distribution more extensive than any mammal, apart from humans. The mouse genome sequencing consortium is a joint project between the whitehead institutemit center for genome research, the washington university genome sequencing center.
Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse mus musculus fabian staubach1,2, anna lorenc1, philipp w. Wildderived inbred strains are available from mus musculus domesticus, mus musculus musculus, mus musculus molossinus, mus musculus castaneus, mus spretus, and mus spicilegus. These reference sequences exist independently of genome builds. Recent advances in genome sequencing of a variety of.
Mus musculus castaneus extends from central asia c afghanistan south of hindu kush, pakistan, peninsular and ne india, e and c nepal. The mouse genome sequencing consortium is a joint project between the whitehead institutemit center for genome research, the washington university genome sequencing center, the wellcome trust sanger. Receptor for medium and longchain free fatty acids ffas. Trem1 triggering receptor expressed on myeloid cells 1. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. The antiinflammatory effects involve inhibition of tak1 through a betaarrestin 2 arrb2tab1dependent effect, but independent of the gqg11coupled pathway. Acts as a receptor for omega3 fatty acids and mediates robust antiinflammatory effects, particularly in macrophages and fat cells. Proteome characterization of used nesting material and. The july 2007 mouse mus musculus genome data were obtained from the build 37 assembly by ncbi and the mouse genome sequencing consortium. The four main types of proteoglycans include hyaluronan ha, which does not occur as a pg but in free form, heparan sulfate proteoglycans hspgs, chondroitin sulfate proteoglycans cspgs, dematan sulfate proteoglycans dspg and keratan sulfate proteoglycans kspgs br. Ffar4 free fatty acid receptor 4 mus musculus mouse. It utilizes the foodstuffs and domiciles of man, as a result of which it has. A genome position can be specified by the accession number of a sequenced genomic region, an mrna or est, a. As the cost of genomescale sequencing continues to decrease and new technologies for genome editing become widely adopted, the laboratory mouse is more important than ever as a model system for understanding the biological significance of human genetic variation and for advancing the basic research needed to support the emergence of genome.
Mice are biologically similar to humans and are thus good models for genetic diseases and research on the immune system. House mouse mus musculus, a mammal of the family muridae of the order rodentia. Mus musculus is one of the most important model organisms in biology and medicine. Involved in cell mobility and transcription regulation through proteinprotein interactions.
Download a free trial for realtime bandwidth monitoring, alerting, and more. Hybrids between mice of the mus musculus complex are viable and most are also. Gjb2 gap junction protein, beta 2 mus musculus house. Genomic resources for wild populations of the house mouse. Mus musculus definition of mus musculus by the free. Mus musculus genome medical definition and pronunciation. In 2003, the first sequenced mouse genome was that of the c57bl6 abbreviated b6 mouse inbred strain, and since then 17 additional mouse inbred strains have been. The mouse genome was sequenced in 2002 and it was shown that almost every gene in the mouse genome had a human homolog. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Download the complete genome for an organism ncbi nih. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. This assembly is used by ucsc to create their mm9 database.
Gjb2 gap junction protein, beta 2 mus musculus house mouse gene id. The source for the genome browser, blat, liftover and other utilities is free for nonprofit academic research and for personal use. This largescale collaborative project, mainly based on the free, willing. Can promote transcription activation through binding to. Interaction between app molecules on neighboring cells promotes synaptogenesis. Here, we report the wholegenome sequencing of two wildderived mouse inbred strains, leweseij and zalendeeij, of mus musculus domesticus origin. Peripheral trem1 responses to brain and intestinal immunogens amplify stroke severity. When comparing the mouse genomic sequence with that of human, the overall. Wild populations of the house mouse mus musculus represent the raw genetic material for the classical inbred strains in biomedical research and are a. The house mouse mus musculus has a longstanding history as a. A set of centrallymaintained and updated scientific databases is made available to users of helix and biowulf.
On account of their abundance, ltr retrotransposons are believed to hold major significance for genome structure and function. We would like to show you a description here but the site wont allow us. Mus musculus brownishgrey old world mouse now a common household pest worldwide house mouse mouse any of numerous small rodents typically. Bandwidth analyzer pack analyzes hopbyhop performance onpremise, in hybrid networks, and in the cloud, and can help identify excessive bandwidth utilization or unexpected application traffic. Ffar2 free fatty acid receptor 2 mus musculus mouse. A number of laws, guidelines and policies exist to protect animals, including mice, from unnecessary pain or distress as part of the research process. Click on a link below to see the available databases. In many cases, the sequence data is segregated into directories for each chromosome. Within that directory a readme file will describe the various files available. The analysis we present is a comprehensive, genomewide analysis of cnvs in mus musculus, which increases the number of known variants in the species and will accelerate the identification of novel variants in future studies. For more information about this assembly, see grcm38 in the ncbi assembly database. The house mouse is distributed almost throughout the world, except the arctic and antarctic. The mouse was the second mammal to have its genome sequenced. Mus musculus synonyms, mus musculus pronunciation, mus musculus translation, english dictionary definition of mus musculus.
Mus musculus genome the genomes of particular nonhuman organisms such as the mouse have been studied for a number of reasons including the need to improve sequencing and analysis techniques. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Data taken from the database must not be reproduced in published lists, online databases, or other such formats, nor redistributed without. More information and statistics download dna sequence fasta. It has become a frequently used model for understanding human disease and development due to its small size, short lifecycle and rapid breeding cycle. The mouse mus musculus is the most commonly used mammal in the laboratory. Long terminal repeat ltr retrotransposons make up a large fraction of the typical mammalian genome. Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of nfr2 pathway. The mitochondrial genome and most of the nuclear genome of classical laboratory inbred strains of m. Its geographic spread has been facilitated by its commensal relationship with man which extends back at least 8,000 years. Wildderived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. Bowtie 2 indexes the genome with an fm index to keep its memory footprint small.
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